17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan

Base Information

Chemical Name:17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan
CAS No.:731791-46-1
Molecular Formula:C₄₃H₅₉N₃O₃Si₂
Molecular Weight:722.131
Hs Code.:

Synonyms:17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan

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Chemical Property of 17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan

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Technology Process of 17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan

There total 3 articles about 17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 235751-97-0
3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan

: 726-42-1
di-p-tolylcarbodiimide

: 731791-46-1
17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1071/CH03199

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 731791-46-1
17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide / 4 h / 20 - 90 °C

2: 98 percent / dimethylformamide / 20 °C

With 1H-imidazole; dmap; In N,N-dimethyl-formamide;
DOI:10.1071/CH03199

Reference yield:

: 466-97-7,13396-02-6,99295-16-6,142864-36-6
normorphine

: 731791-46-1
17-(N',N''-bis(p-tolyl)-2-carboxamidino)-3,6-bis(tert-butyl(dimethyl)silyloxy)-7,8-didehydro-4,5-epoxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide / 4 h / 20 - 90 °C

2: 98 percent / dimethylformamide / 20 °C

With 1H-imidazole; dmap; In N,N-dimethyl-formamide;
DOI:10.1071/CH03199