(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid

Base Information

Chemical Name:(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid
CAS No.:133683-11-1
Molecular Formula:C₁₇H₂₂N₂O₅
Molecular Weight:334.372
Hs Code.:

Synonyms:(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid

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Technology Process of (S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid

There total 2 articles about (S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133683-10-0
(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

: 133683-11-1
(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 1h; under 760 Torr;
DOI:10.1248/cpb.45.1631

Reference yield:

: (S)-2-[(4-Oxo-piperidine-1-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

: 133683-11-1
(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / p-toluenesulfonic acid / benzene / 2 h / Heating

2: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; benzene;
DOI:10.1248/cpb.45.1631

Reference yield: 51.0%

: 133683-11-1
(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid

: 146682-56-6
(S)-N-((1S,2S,4S)-1-Cyclohexylmethyl-2,4-dihydroxy-5-methyl-hexyl)-3-(1H-imidazol-4-yl)-2-methylamino-propionamide

: 198989-67-2
1,4-Dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid ((S)-1-{[(S)-1-((1S,2S,4S)-1-cyclohexylmethyl-2,4-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-amide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) 0 deg C, 2 h, 2.) RT, 20 h;
DOI:10.1248/cpb.45.1631