(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester
CAS No.:133683-10-0
Molecular Formula:C₂₄H₂₈N₂O₅
Molecular Weight:424.497
Hs Code.:

Synonyms:(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

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Chemical Property of (S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

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Technology Process of (S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

There total 1 articles about (S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 107-21-1
ethylene glycol

: (S)-2-[(4-Oxo-piperidine-1-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

: 133683-10-0
(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 2h; Heating;
DOI:10.1248/cpb.45.1631

Reference yield:

: 133683-10-0
(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

: 133683-11-1
(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 1h; under 760 Torr;
DOI:10.1248/cpb.45.1631

Reference yield:

: 133683-10-0
(S)-2-[(1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

: 4-Oxo-piperidine-1-carboxylic acid ((S)-1-{[(S)-1-((1S,2S,4S)-1-cyclohexylmethyl-2,4-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr

2: 51 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, 20 h

3: 22 percent / p-toluenesulfonic acid, H₂O / methanol / 24 h / Heating

With water; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1631