(S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid

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Chemical Name:(S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid
CAS No.:144333-49-3
Molecular Formula:C₄₄H₅₀N₄O₁₂
Molecular Weight:826.901
Hs Code.:

(S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid

Synonyms:(S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid

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Chemical Property of (S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid

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Technology Process of (S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid

There total 8 articles about (S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 144333-39-1
(S)-3-[3-(4-{(S)-2-Acetylamino-2-[(S)-2-(4-hydroxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-ethyl}-phenoxy)-4-benzyloxycarbonylamino-phenyl]-2-tert-butoxycarbonylamino-propionic acid ethyl ester

: 144333-49-3
(S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 25 ℃; for 2h;
DOI:10.1016/S0040-4039(00)61289-3

Reference yield:

: 40385-54-4
3-bromo-4-nitrotoluene

: 144333-49-3
(S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: CrO₃, conc. H₂SO₄, Ac₂O / ethanol; H₂O / 1 h / Heating

2: 61 percent / NaH, CuBr*Me₂S / nitrobenzene / 7 h / 110 °C

3: 75 percent / t-BuOK / CH₂Cl₂ / 2 h / -60 °C

4: 98 percent / H₂ / 10percent Pd-C / methanol / 10 h / 25 °C

5: 86 percent / DMAP, pyridine / CH₂Cl₂ / 3 h / 0 °C

6: 88 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 10 h / 0 °C

7: 1.) 1-hydroxybenzotriazole (HOBT), 1,3-dicyclohexylcarbodiimide (DCC) / 1.) CH₂Cl₂, 0 deg C, 2.) 25 deg C, 1 h

8: 90 percent / n-Bu₄NF / tetrahydrofuran; dimethylformamide / 2 h / 25 °C

With pyridine; chromium(VI) oxide; dmap; lithium hydroxide; copper(I) bromide dimethylsulfide complex; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)61289-3

Reference yield:

: 101682-68-2
3-bromo-4-nitrobenzaldehyde

: 144333-49-3
(S)-2-((S)-2-Acetylamino-3-{4-[2-benzyloxycarbonylamino-5-((S)-2-tert-butoxycarbonylamino-2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-propionylamino)-3-(4-hydroxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 61 percent / NaH, CuBr*Me₂S / nitrobenzene / 7 h / 110 °C

2: 75 percent / t-BuOK / CH₂Cl₂ / 2 h / -60 °C

3: 98 percent / H₂ / 10percent Pd-C / methanol / 10 h / 25 °C

4: 86 percent / DMAP, pyridine / CH₂Cl₂ / 3 h / 0 °C

5: 88 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 10 h / 0 °C

6: 1.) 1-hydroxybenzotriazole (HOBT), 1,3-dicyclohexylcarbodiimide (DCC) / 1.) CH₂Cl₂, 0 deg C, 2.) 25 deg C, 1 h

7: 90 percent / n-Bu₄NF / tetrahydrofuran; dimethylformamide / 2 h / 25 °C

With pyridine; dmap; lithium hydroxide; copper(I) bromide dimethylsulfide complex; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)61289-3