40385-54-4Relevant articles and documents
Nitration of deactivated aromatic compounds via mechanochemical reaction
Wu, Jian-Wei,Zhang, Pu,Guo, Zhi-Xin
supporting information, (2021/05/05)
A variety of deactivated arenes were nitrated to their corresponding nitro derivatives in excellent yields under high-speed ball milling condition using Fe(NO3)3·9H2O/P2O5 as nitrating reagent. A radical involved mechanism was proposed for this facial, eco-friendly, safe, and effective nitration reaction.
Design, synthesis and structure–activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands
Szymańska, Ewa,Cha?upnik, Paulina,Szczepańska, Katarzyna,Cu?ado Moral, Ana Maria,Pickering, Darryl S.,Nielsen, Birgitte,Johansen, Tommy N.,Kie?-Kononowicz, Katarzyna
supporting information, p. 5568 - 5572 (2016/11/09)
A new series of carboxyaryl-substituted phenylalanines was designed, synthesized and pharmacologically characterized in vitro at native rat ionotropic glutamate receptors as well as at cloned homomeric kainate receptors GluK1–GluK3. Among them, six compounds bound to GluK1 receptor subtypes with reasonable affinity (Kivalues in the range of 4.9–7.5?μM). A structure–activity relationship (SAR) for the obtained series, focused mainly on the pharmacological effect of structural modifications in the 4- and 5-position of the phenylalanine ring, was established. To illustrate the results, molecular docking of the synthesized series to the X-ray structure of GluK1 ligand binding core was performed. The influence of individual substituents at the phenylalanine ring for both the affinity and selectivity at AMPA, GluK1 and GluK3 receptors was analyzed, giving directions for future studies.
Reaction of dimethyldioxirane with aniline hydrohalides
Ivanova,Grabovskii,Kabal'nova,Shereshovets
, p. 2101 - 2105 (2007/10/03)
Oxidation of aromatic amine hydrohalides (aniline hydrochloride, hydrobromide, and hydrofluoride; 4-methylaniline hydrochloride and hydrobromide; 3-methylaniline and N,N-diethylaniline hydrochlorides) with dimethyldioxirane was studied. The product composition was analyzed in relation to the reactant ratio.