N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride

Base Information

Chemical Name:N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride
CAS No.:78403-08-4
Molecular Formula:C₂₂H₁₆ClNO₄S
Molecular Weight:425.892
Hs Code.:

N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz<b,e>-azepine-3-carbonyl chloride

Synonyms:N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride

There total 7 articles about N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78382-90-8
2-[Benzyl-(toluene-4-sulfonyl)-amino]-terephthaloyl dichloride

: 78403-08-4
N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride

Guidance literature:: With aluminium trichloride; In dichloromethane; at 0 ℃; for 0.5h; Yield given;
DOI:10.1021/jm00141a018

Reference yield:

: 68218-51-9
N-(p-toluenesulphonyl)-2,5-dimethoxycarbonylanilide

: 78403-08-4
N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride / 1.0 DMF, 2.) DMF, 16 h

2: 90 percent / aq. methanolic sodium hydroxide / 3 h / Heating

3: thionyl chloride

4: aluminum chloride / CH₂Cl₂ / 0.5 h / 0 °C

With sodium hydroxide; aluminium trichloride; thionyl chloride; sodium hydride; In dichloromethane;
DOI:10.1021/jm00141a018

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 78403-08-4
N-(p-toluenesulfonyl)-5,6-dihydro-11-oxodibenz-azepine-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / pyridine / 24 h / Ambient temperature

2: 1.) sodium hydride / 1.0 DMF, 2.) DMF, 16 h

3: 90 percent / aq. methanolic sodium hydroxide / 3 h / Heating

4: thionyl chloride

5: aluminum chloride / CH₂Cl₂ / 0.5 h / 0 °C

With sodium hydroxide; aluminium trichloride; thionyl chloride; sodium hydride; In pyridine; dichloromethane;
DOI:10.1021/jm00141a018