(1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

Base Information

Chemical Name:(1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol
CAS No.:1357261-76-7
Molecular Formula:C₁₇H₂₇FO₂Si
Molecular Weight:310.484
Hs Code.:

Synonyms:(1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

Suppliers and Price of (1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

There total 12 articles about (1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1357261-89-2
(1S,2S,3S,4R)-1-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)-3,4-epoxycyclopentane

: 1357261-76-7
(1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 20 ℃; for 1h; regioselective reaction;
DOI:10.1055/s-0031-1289863

Reference yield: 33.0%

: C₁₇H₂₃FO₂Si

: 1357261-76-7
(1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

: 1357261-80-3
C₁₇H₂₇FO₂Si

: C₁₇H₂₇FO₂Si

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h;
DOI:10.1039/d0cc02621b

Reference yield:

: 1357261-90-5
C₁₁H₁₆O₆

: 1357261-76-7
(1R,2S,3S)-3-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)cyclopentan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: novozyme 435 / 0.17 h / 20 °C / Enzymatic reaction

2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: lithium triethylborohydride / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; n-butyllithium; novozyme 435; lithium triethylborohydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289863