Technology Process of (1S,2S,3S,4R)-1-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)-3,4-epoxycyclopentane
There total 8 articles about (1S,2S,3S,4R)-1-(tert-butyldimethylsilyloxy)-2-(4-fluorophenyl)-3,4-epoxycyclopentane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
DOI:10.1055/s-0031-1289863
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: novozyme 435 / 0.17 h / 20 °C / Enzymatic reaction
2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C
4.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C
With
1H-imidazole; n-butyllithium; novozyme 435; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289863
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.67 h / 20 °C
3.1: pyridine / dichloromethane / 1 h / 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
5.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C
5.2: 0 - 20 °C
6.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 0 - 20 °C
7.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C
With
pyridine; 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0031-1289863
