1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone

Base Information

Chemical Name:1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone
CAS No.:442128-44-1
Molecular Formula:C₂₀H₂₄N₂O₂
Molecular Weight:324.423
Hs Code.:

Synonyms:1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone

Suppliers and Price of 1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone

There total 3 articles about 1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 97674-02-7
tributyl(1-ethoxyvinyl)stannane

: 442128-19-0
1-[2-(4-tert-butylphenyl)-6-chloro-pyrimidin-4-yl]-ethyl ketone

: 442128-44-1
1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 80 ℃; for 12h;
DOI:10.1021/jo702495u

Reference yield:

: 1011806-44-2
2-(4-tert-butylphenyl)-4-chloro-6-(1-ethoxyvinyl)-pyrimidine

: 442128-44-1
1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / acetone / 20 °C

2: [Pd(P(C₆H₅)3)4]Cl₂ / dimethylformamide / 6 h / 80 °C

With hydrogenchloride; tetrakis(triphenylphosphine)palladium dichloride; In N,N-dimethyl-formamide; acetone; 2: Stille coupling reaction;
DOI:10.1002/1521-3773(20020402)41:7<1195::AID-ANIE1195>3.0.CO;2-L

Reference yield:

: 442128-03-2
2-(4-tert-butylphenyl)-4,6-dichloropyrimidine

: 442128-44-1
1-[2-(4-tert-butylphenyl)-6-(1-ethoxyvinyl)-pyrimidin-4-yl]-ethyl ketone

Guidance literature:: Multi-step reaction with 3 steps

1: [Pd(P(C₆H₅)3)4]Cl₂ / dimethylformamide / 6 h / 80 °C

2: aq. HCl / acetone / 20 °C

3: [Pd(P(C₆H₅)3)4]Cl₂ / dimethylformamide / 6 h / 80 °C

With hydrogenchloride; tetrakis(triphenylphosphine)palladium dichloride; In N,N-dimethyl-formamide; acetone; 1: Stille coupling reaction / 3: Stille coupling reaction;
DOI:10.1002/1521-3773(20020402)41:7<1195::AID-ANIE1195>3.0.CO;2-L