(S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide

Base Information

Chemical Name:(S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide
CAS No.:758698-37-2
Molecular Formula:C₂₈H₃₂N₄O₃
Molecular Weight:472.587
Hs Code.:

Synonyms:(S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide

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Chemical Property of (S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide

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Technology Process of (S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide

There total 5 articles about (S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 92-95-5
4-biphenyl isocyanate

: 851967-60-7
[(S)-2-phenyl-1-(2-pyrrolidin-1-yl-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 758698-37-2
(S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide

Guidance literature:: [(S)-2-phenyl-1-(2-pyrrolidin-1-yl-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 4h;

4-biphenyl isocyanate; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 758698-37-2
(S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; N-methyl-morpholine / dimethylformamide / 14 h / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 17 h / 20 °C

3: CH₂Cl₂

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.05.042

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 758698-37-2
(S)-2-[3-(4-phenoxy-phenyl)-ureido]-3-phenyl-N-(2-pyrrolidin-1-yl-ethyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; N-methyl-morpholine / dimethylformamide / 14 h / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 17 h / 20 °C

3: CH₂Cl₂

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.05.042