[(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane
CAS No.:90941-94-9
Molecular Formula:C₂₈H₄₂O₄Si
Molecular Weight:470.725
Hs Code.:

Synonyms:[(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane

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Chemical Property of [(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane

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Technology Process of [(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane

There total 8 articles about [(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (2S,4S)-6-Benzhydryloxy-1-(tert-butyl-dimethyl-silanyloxy)-hexane-2,4-diol

: 77-76-9
2,2-dimethoxy-propane

: 90941-94-9
[(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: CSA catalyst; In acetone; Ambient temperature;
DOI:10.1021/jo00189a046

Reference yield:

: 90941-89-2
(E)-4-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-but-2-en-1-ol

: 90941-94-9
[(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / Ti(O-i-Pr)4, diethyl (-)-tartrate, TBHP / CH₂Cl₂ / -20 °C

2: 76 percent / Redal / tetrahydrofuran / -20 °C

3: 65 percent / NaH / hexamethylphosphoric acid triamide; dimethylformamide / Ambient temperature

4: 100 percent / 0.8percent H₂SO₄ / methanol / Ambient temperature

5: 85 percent / imidazole / tetrahydrofuran / Ambient temperature

6: 98 percent / CSA catalyst / acetone / Ambient temperature

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; sulfuric acid; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; CSA catalyst; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00189a046

Reference yield:

: 90941-92-7
(S)-4-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-butane-1,3-diol

: 90941-94-9
[(4S,6S)-6-(2-Benzhydryloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / NaH / hexamethylphosphoric acid triamide; dimethylformamide / Ambient temperature

2: 100 percent / 0.8percent H₂SO₄ / methanol / Ambient temperature

3: 85 percent / imidazole / tetrahydrofuran / Ambient temperature

4: 98 percent / CSA catalyst / acetone / Ambient temperature

With 1H-imidazole; sulfuric acid; sodium hydride; CSA catalyst; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00189a046