4-(1-trifluoromethyl-2-chloroethylthio)-6-oxatricyclo<3.2.1.1^3,8>nonan-7-one

Base Information

• Chemical Name: 4-(1-trifluoromethyl-2-chloroethylthio)-6-oxatricyclo<3.2.1.1^3,8>nonan-7-one
• CAS No.: 128856-03-1
• Molecular Formula: C₁₁H₁₂ClF₃O₂S
• Molecular Weight: 300.729
• Mol file: 128856-03-1.mol

Synonyms:4-(1-trifluoromethyl-2-chloroethylthio)-6-oxatricyclo<3.2.1.1^3,8>nonan-7-one

Chemical Property of 4-(1-trifluoromethyl-2-chloroethylthio)-6-oxatricyclo<3.2.1.1^3,8>nonan-7-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-trifluoromethyl-2-chloroethylthio)-6-oxatricyclo<3.2.1.1^3,8>nonan-7-one

There total 2 articles about 4-(1-trifluoromethyl-2-chloroethylthio)-6-oxatricyclo<3.2.1.1^3,8>nonan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

endo-norbornenecarboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) + α-Trifluoromethyl-β-chloroethylsulfenyl chloride (87612-17-7) → 4-(1-trifluoromethyl-2-chloroethylthio)-6-oxatricyclo<3.2.1.13,8>nonan-7-one (128856-03-1)

Guidance literature:

With hydrogenchloride; lithium hydroxide; silver perchlorate; zirconocene dichloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, 0 degC, 1.5 h; 2.) THF, H₂O, r.t., overnight;

DOI:10.1016/0040-4020(94)01140-U

Reference yield:

endo-norbornenecarboxylic acid (120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7) + α-Trifluoromethyl-β-chloroethylsulfenyl chloride (87612-17-7) + bis<(S)-1-phenylethyl>carbodiimide (57122-22-2) → 4-(1-trifluoromethyl-2-chloroethylthio)-6-oxatricyclo<3.2.1.13,8>nonan-7-one (128856-03-1) + 1-((1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carbonyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea (119945-16-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / LiAlH₄

2: 93 percent / pyridine

3: 1.) B₂H₆, 2.) NaOH, H₂O₂ / 1.) THF, 0 deg C, 1 h, 2.) 30 min

With sodium hydroxide; lithium aluminium tetrahydride; dihydrogen peroxide; diborane; In pyridine;

upstream raw materials:

endo-norbornenecarboxylic acid

α-Trifluoromethyl-β-chloroethylsulfenyl chloride

bis<(S)-1-phenylethyl>carbodiimide