(2-fluoro-5-iodo-phenyl)-methanol

Base Information

• Chemical Name: (2-fluoro-5-iodo-phenyl)-methanol
• CAS No.: 438050-27-2
• Molecular Formula: C₇H₆FIO
• Molecular Weight: 252.027
• Hs Code.: 2906290090
• Mol file: 438050-27-2.mol

Synonyms:(2-fluoro-5-iodo-phenyl)-methanol

Chemical Property of (2-fluoro-5-iodo-phenyl)-methanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-5-iodobenzyl alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-fluoro-5-iodo-phenyl)-methanol

There total 2 articles about (2-fluoro-5-iodo-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Fluoro-5-iodo-benzaldehyde (146137-76-0) → (2-fluoro-5-iodo-phenyl)-methanol (438050-27-2)

Guidance literature:

2-Fluoro-5-iodo-benzaldehyde; With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1.33333h;

With water; In ethyl acetate;

Reference yield:

2-fluoro-5-iodobenzoic acid (124700-41-0) → (2-fluoro-5-iodo-phenyl)-methanol (438050-27-2)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 70 ℃; for 2h; Inert atmosphere;

Reference yield: 99.0%

(2-fluoro-5-iodo-phenyl)-methanol (438050-27-2) → 1-Fluoro-2-fluoromethyl-4-iodo-benzene (1065168-32-2)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; for 1h;

upstream raw materials:

2-Fluoro-5-iodo-benzaldehyde

2-fluoro-5-iodobenzoic acid

Downstream raw materials:

5-(4-fluoro-3-hydroxymethylphenylethynyl)-nicotinonitrile

(R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester

1-Fluoro-2-fluoromethyl-4-iodo-benzene

2-(bromomethyl)-1-fluoro-4-iodobenzene

Refernces

• 1、 -. "2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS". Page/Page column 60. . Retrieved 2013/05/23.
• 2、 -. "PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS". Page/Page column 41. . Retrieved 2008/06/13.