(R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester

Base Information

• Chemical Name: (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester
• CAS No.: 438050-28-3
• Molecular Formula: C₁₉H₂₆FIN₂O₄
• Molecular Weight: 492.329
• Mol file: 438050-28-3.mol

Synonyms:(R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester

Chemical Property of (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester

There total 5 articles about (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-fluoro-5-iodo-phenyl)-methanol (438050-27-2) + (R)-4-chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester (438050-09-0) → (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester (438050-28-3)

Guidance literature:

In N-methyl-acetamide;

Reference yield:

(R)-1-benzyl-3-ethylpiperazine (347195-55-5) → (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester (438050-28-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / palladium / ethanol

2: triethylamine / methanol; dichloromethane

3: pyridine / dichloromethane

4: N-methyl-acetamide

With pyridine; hydrogenchloride; triethylamine; palladium; In N-methyl-acetamide; methanol; ethanol; dichloromethane;

Reference yield:

(R)-2-ethylpiperazine dihydrochloride (128427-05-4,438050-07-8) → (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-iodo-benzyl)ester (438050-28-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / methanol; dichloromethane

2: pyridine / dichloromethane

3: N-methyl-acetamide

With pyridine; triethylamine; In N-methyl-acetamide; methanol; dichloromethane;

upstream raw materials:

(2-fluoro-5-iodo-phenyl)-methanol

(R)-4-chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester

(R)-2-ethylpiperazine dihydrochloride

(R)-1-benzyl-3-ethylpiperazine

Downstream raw materials:

(R)-2-ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-fluoro-5-hydroxy-benzyl)ester