Technology Process of (3-(allyloxy)-1,1,2,2-tetrafluoro-3-phenylpropyl)(phenyl)sulfane
There total 4 articles about (3-(allyloxy)-1,1,2,2-tetrafluoro-3-phenylpropyl)(phenyl)sulfane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,2,3,3-tetrafluoro-1-phenyl-3-(phenylthio)propan-1-ol;
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Inert atmosphere;
allyl bromide;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/ejoc.201100667
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: magnesium / tetrahydrofuran / -78 - 20 °C
2.1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
With
sodium hydride; magnesium; tetrabutylammonium triphenyldifluorosilicate;
In
tetrahydrofuran;
DOI:10.1002/ejoc.201100667
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide
1.2: -50 - 20 °C
2.1: magnesium / tetrahydrofuran / -78 - 20 °C
3.1: tetrabutylammonium triphenyldifluorosilicate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
4.2: 2 h / 20 °C / Inert atmosphere
With
sodium hydride; magnesium; tetrabutylammonium triphenyldifluorosilicate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100667
