1333418-94-2

Upstream product

• 1000293-91-3 trimethyl(1,1,2,2-tetrafluoro-2-(phenylsulfanyl)ethyl)silane 
• 100-52-7 benzaldehyde 
• 108-98-5 thiophenol 
• 83015-33-2 (2-bromo-1,1,2,2-tetrafluoroethylsulfanyl)benzene 

Downstream Products

• 1333419-08-1 (3-(allyloxy)-1,1,2,2-tetrafluoro-3-phenylpropyl)(phenyl)sulfane 
• 1333419-14-9 (E)-(3-(cinnamyloxy)-1,1,2,2-tetrafluoro-3-phenylpropyl)(phenyl)sulfane 

Relevant academic research and scientific papers

Nucleophilic tetrafluoroethylation employing in situ formed organomagnesium reagents

Tetrafluoroalkyl bromides are metalated with equimolar iPrMgCl·LiCl (Turbo Grignard) to form organomagnesium compounds which are stable at low temperatures and react with various electrophiles (aldehydes, ketones, CO2, cyclic sulfate and sulfamidate, N-sulfonylimines, nitrone, chlorophosphate, nonaflyl azide) to afford novel functionalized tetrafluoroethylene-containing products. Ease of operation, excellent selectivity, high nucleophilicity, and enhanced stability of the reactive species together with a broad substrate scope comprise a highly attractive nucleophilic tetrafluoroethylation protocol affording unique synthetic building blocks.

Development of PhSCF2CF2SiMe3 as a tandem anion and radical tetrafluoroethylene equivalent: Preparation of tetrafluoroethyl-substituted alcohols and tetrafluorotetrahydropyrans

PhSCF2CF2SiMe3 (1) was developed as a tandem anion and radical tetrafluoroethylene equivalent for the introduction of aCF2CF2 moiety. Fluoride-initiated nucleophilic additions of 1 to carbonyl compoun