1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole

Base Information

• Chemical Name: 1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole
• CAS No.: 99793-19-8
• Molecular Formula: C₂₁H₁₃Cl₄N₃S
• Molecular Weight: 481.232
• Mol file: 99793-19-8.mol

Synonyms:1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole

Chemical Property of 1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole

There total 3 articles about 1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1,2-dichloro-4-(iodomethyl)benzene (142523-67-9) + 1,5-bis(4-chlorophenyl)-1,2-dihydro-1,2,4-triazole-3-thione (99793-83-6) → 1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole (99793-19-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 1h; Heating;

DOI:10.1016/0223-5234(90)90015-U

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → 1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole (99793-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NaOH / 1.) benzene, 80 deg C, 90 min, 2.) 25percent aq. methanol, 50 deg C

2: 64 percent / aq. NaOH / ethanol / 1 h / Heating

With sodium hydroxide; In ethanol;

DOI:10.1016/0223-5234(90)90015-U

Reference yield:

p-chlorophenyl thiosemicarbazide (7382-41-4) → 1,5-Bis-(4-chloro-phenyl)-3-(3,4-dichloro-benzylsulfanyl)-1H-[1,2,4]triazole (99793-19-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NaOH / 1.) benzene, 80 deg C, 90 min, 2.) 25percent aq. methanol, 50 deg C

2: 64 percent / aq. NaOH / ethanol / 1 h / Heating

With sodium hydroxide; In ethanol;

DOI:10.1016/0223-5234(90)90015-U

upstream raw materials:

1,2-dichloro-4-(iodomethyl)benzene

1,5-bis(4-chlorophenyl)-1,2-dihydro-1,2,4-triazole-3-thione

4-chloro-benzoyl chloride

p-chlorophenyl thiosemicarbazide