(4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide

Base Information

Chemical Name:(4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide
CAS No.:314049-49-5
Molecular Formula:C₂₂H₁₉NO₂Se
Molecular Weight:408.358
Hs Code.:

Synonyms:(4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide

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Chemical Property of (4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide

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Technology Process of (4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide

There total 3 articles about (4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 314049-44-0
(4S,5S)-2-(4-tert-butyldimethylsilyloxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide

: 314049-49-5
(4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0022-328X(00)00488-5

Reference yield:

: 1666-13-3
diphenyl diselenide

: 314049-49-5
(4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / TMEDA; sec-butyllithium / cyclohexane; hexane; tetrahydrofuran / 24 h / 20 °C

2: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

With N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; 1: Arylation / 2: desilylation;
DOI:10.1016/S0022-328X(00)00488-5

Reference yield:

: 175477-26-6
(4S,5S)-4-tert-Butyldimethylsiloxymethyl-2,5-diphenyl-4,5-dihydro-1,3-oxazole

: 314049-49-5
(4S,5S)-2-(4-hydroxymethyl-5-phenyloxazolin-2-yl)phenyl, phenyl selenide

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / TMEDA; sec-butyllithium / cyclohexane; hexane; tetrahydrofuran / 24 h / 20 °C

2: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

With N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; 1: Arylation / 2: desilylation;
DOI:10.1016/S0022-328X(00)00488-5