3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol

Base Information

Chemical Name:3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol
CAS No.:1610763-27-3
Molecular Formula:C₃₂H₃₁NO₄
Molecular Weight:493.602
Hs Code.:

Synonyms:3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol

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Chemical Property of 3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol

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Technology Process of 3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol

There total 10 articles about 3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1610763-25-1
2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-ol

: 627-18-9
1-bromo-3-propanol

: 1610763-27-3
3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol

Guidance literature:: With potassium carbonate; In acetone; at 60 ℃; for 90h;
DOI:10.1021/jm500351m

Reference yield:

: 7451-98-1
3',4'-dihydroxypropiophenone

: 1610763-27-3
3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: Reflux

2.1: acetic acid; bromine / 0.5 h / 20 °C

3.1: triethylamine / ethanol / 16 h / 80 °C / Inert atmosphere

3.2: 14 h / 115 °C / Inert atmosphere; Sealed tube

4.1: potassium carbonate / acetone / 90 h / 60 °C

With bromine; potassium carbonate; acetic acid; triethylamine; In ethanol; acetone; 3.1: |Bischler-Moehlau Indole Synthesis / 3.2: |Bischler-Moehlau Indole Synthesis;
DOI:10.1021/jm500351m

Reference yield:

: 17269-65-7
1-(3,4-bis(benzyloxy)phenyl)propan-1-one

: 1610763-27-3
3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; bromine / 0.5 h / 20 °C

2.1: triethylamine / ethanol / 16 h / 80 °C / Inert atmosphere

2.2: 14 h / 115 °C / Inert atmosphere; Sealed tube

3.1: potassium carbonate / acetone / 90 h / 60 °C

With bromine; potassium carbonate; acetic acid; triethylamine; In ethanol; acetone; 2.1: |Bischler-Moehlau Indole Synthesis / 2.2: |Bischler-Moehlau Indole Synthesis;
DOI:10.1021/jm500351m