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Usage

Uses

Used in Organic Synthesis:
3',4'-Dibenzyloxy-1-phenylpropiophenone is used as a synthetic intermediate for the production of a wide range of organic compounds. Its unique structure allows for the formation of various derivatives, making it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3',4'-Dibenzyloxy-1-phenylpropiophenone is used as a key component in the development of new drugs. Its ability to form diverse derivatives enables the creation of novel molecules with potential therapeutic applications, contributing to the advancement of drug discovery and development.
Used in Agrochemical Industry:
3',4'-Dibenzyloxy-1-phenylpropiophenone also finds application in the agrochemical industry, where it is employed in the synthesis of new pesticides and other crop protection agents. Its versatility in organic synthesis allows for the development of innovative products that can address the evolving needs of modern agriculture.

Upstream product

• 7451-98-1 3',4'-dihydroxypropiophenone 
• 100-39-0 benzyl bromide 

Downstream Products

• 1570-05-4 3,4-bis(benzyloxy)benzoic acid 
• 57541-13-6 3,4-bis(benzyloxy)phenyl 1-(tert-butylamino)ethyl ketone 
• 1610763-23-9 1-(3,4-bis(benzyloxy)phenyl)-2-((4-(methoxymethoxy)phenyl)amino)propan-1-one 
• 1610763-25-1 2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-ol 
• 1610763-27-3 3-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)-propan-1-ol 
• 1610763-29-5 2-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)ethyl acetate 
• 1610763-31-9 2-((2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indol-5-yl)oxy)ethanol 
• 1610763-32-0 4-(5-hydroxy-3-methyl-1H-indol-2-yl)benzene-1,2-diol 
• 1610763-34-2 4-(5-(2-hydroxyethoxy)-3-methyl-1H-indol-2-yl)benzene-1,2-diol 
• 1610763-36-4 4-(5-(3-hydroxypropoxy)-3-methyl-1H-indol-2-yl)benzene-1,2-diol 
• 1610763-43-3 5-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1-propyl-1H-indole 
• 1610763-44-4 1-benzyl-5-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)-3-methyl-1H-indole 
• 1610763-45-5 4-(5-hydroxy-1,3-dimethyl-1H-indol-2-yl)benzene-1,2-diol 
• 1610763-46-6 4-(5-hydroxy-3-methyl-1-propyl-1H-indol-2-yl)benzene-1,2-diol 

Relevant academic research and scientific papers

Synthesis, Antiproliferative Effect, and Topoisomerase II Inhibitory Activity of 3-Methyl-2-phenyl-1 H-indoles

A series of 3-methyl-2-phenyl-1H-indoles was prepared and investigated for antiproliferative activity on three human tumor cell lines, HeLa, A2780, and MSTO-211H, and some structure-activity relationships were drawn up. The GI50 values of the most potent compounds (32 and 33) were lower than 5 μM in all tested cell lines. For the most biologically relevant derivatives, the effect on human DNA topoisomerase II relaxation activity was investigated, which highlighted the good correlation between the antiproliferative effect and topoisomerase II inhibition. The most potent derivative, 32, was shown to induce the apoptosis pathway. The obtained results highlight 3-methyl-2-phenyl-1H-indole as a promising scaffold for further optimization of compounds with potent antiproliferative and antitopoisomerase II activities.

A straightforward and versatile protocol for the direct conversion of benzylic azides to ketones and aldehydes

The synthesis of carbonyl compounds from benzylic azides through benzylideneamides is described for the first time. NaH-mediated activation of benzyl azides allows a rapid water-promoted oxidation under a facile protocol with good yields.

Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane x receptor antagonists

Pregnane X receptor (PXR), a member of the NR1I nuclear receptor family, acts as a xenobiotic sensor and a paramount transcriptional regulator of drug-metabolizing enzymes and transporters. The overexpression of PXR in various cancer cells indicates the importance of PXR as a drug target for countering multidrug resistance in anticancer treatments. We describe the discovery of novel bazedoxifene-scaffold-based PXR antagonists inspired by the marine sulfated steroids solomonsterol A and B as natural leads. A luciferase reporter assay on a PXR-transfected HepG2 cell line identified compounds 19-24 as promising PXR antagonists. Further structure-activity relationship studies of the most active PXR antagonist from the series (compound 20, IC50 = 11 μM) revealed the importance of hydroxyl groups as hydrogen-bond donors for PXR antagonistic activity. PXR antagonists 20 and 24 (IC50 = 14 μM), in addition to the downregulation of PXR expression, exhibited inhibition of PXR-induced CYP3A4 expression, which illustrates their potential to suppress PXR-regulated phase-I drug metabolism.