3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane

Base Information

• Chemical Name: 3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane
• CAS No.: 934559-12-3
• Molecular Formula: C₄₃H₅₀N₂O₆
• Molecular Weight: 690.88

Synonyms:3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane

Chemical Property of 3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane

Chemical Property:

Purity/Quality:

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Technology Process of 3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane

There total 4 articles about 3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1,N3-di{(1R)-1-[4-(benzyloxy)phenyl]-2-hydroxyethyl}-2,2-diethylmanonamide (600738-27-0) → 3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane (934559-12-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd/C / methanol / 18 h / 20 °C / 3750.38 Torr

2: 64 percent / K₂CO₃ / acetonitrile / 18 h / Heating

3: 73 percent / triphosgene; triphenylphosphane / CH₂Cl₂ / 1 h / 20 °C

4: K₂CO₃ / acetonitrile / 18 h / Heating

With bis(trichloromethyl) carbonate; hydrogen; potassium carbonate; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;

DOI:10.1002/ejoc.200600827

Reference yield:

2,2-diethyl-N1,N3-bis[(R)-2-hydroxy-1-(4-hydroxyphenyl)ethyl]malonamide (317373-77-6) → 3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane (934559-12-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / K₂CO₃ / acetonitrile / 18 h / Heating

2: 73 percent / triphosgene; triphenylphosphane / CH₂Cl₂ / 1 h / 20 °C

3: K₂CO₃ / acetonitrile / 18 h / Heating

With bis(trichloromethyl) carbonate; potassium carbonate; triphenylphosphine; In dichloromethane; acetonitrile;

DOI:10.1002/ejoc.200600827

Reference yield:

N1,N3-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-hydroxyethyl}-2,2-dithylmalonamide (317373-80-1) → 3,3-bis{(4R)-4-[4-(4-phenoxybutoxy)phenyl]-4,5-dihydro-1,3-oxazol-2-yl}pentane (934559-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / triphosgene; triphenylphosphane / CH₂Cl₂ / 1 h / 20 °C

2: K₂CO₃ / acetonitrile / 18 h / Heating

With bis(trichloromethyl) carbonate; potassium carbonate; triphenylphosphine; In dichloromethane; acetonitrile;

DOI:10.1002/ejoc.200600827

upstream raw materials:

N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-chloroethyl}-2,2-dithylmalonamide

phenol

2,2-diethyl-N¹,N³-bis[(R)-2-hydroxy-1-(4-hydroxyphenyl)ethyl]malonamide

N¹,N³-bis{(R)-1-[4-(4-bromobutoxy)phenyl]-2-hydroxyethyl}-2,2-dithylmalonamide

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