(2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid

Base Information

Chemical Name:(2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid
CAS No.:238746-11-7
Molecular Formula:C₁₈H₂₇NO₆
Molecular Weight:353.415
Hs Code.:

Synonyms:(2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid

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Chemical Property of (2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid

Chemical Property:

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Technology Process of (2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid

There total 6 articles about (2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 238746-03-7
(2R,3S)-2-azido-4-(p-methoxybenzyloxy)-3-methyl-1-butanol

: 238746-11-7
(2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10 percent Pd/C / methanol / 0.67 h

2: CH₂Cl₂

3: 94 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

4: NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; Dess-Martin periodane; palladium on activated charcoal; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ja9811243

Reference yield:

: (1R,2R,6S,8R)-4-[(2S,3S)-2-Azido-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0^2,6]decane

: 238746-11-7
(2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / H₂O₂, aq. NaOH

2: 100 percent / H₂ / 10 percent Pd/C / methanol / 0.67 h

3: CH₂Cl₂

4: 94 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

5: NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

With sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; hydrogen; dihydrogen peroxide; Dess-Martin periodane; palladium on activated charcoal; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ja9811243

Reference yield:

: 238746-09-3
(2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanal

: 238746-11-7
(2R,3S)-2-tert-butoxycarbonylamino-4-(p-methoxybenzyloxy)-3-methylbutanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol;
DOI:10.1021/ja9811243