methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate

Base Information

• Chemical Name: methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate
• CAS No.: 468096-16-4
• Molecular Formula: C₁₃H₁₁ClN₂O₂S₂
• Molecular Weight: 326.828
• Mol file: 468096-16-4.mol

Synonyms:methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate

Chemical Property of methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate

There total 1 articles about methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

Methyl 2-aminothiophene-3-carboxylate (4651-81-4) + 4-Chlorophenyl isothiocyanate (2131-55-7) → methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate (468096-16-4)

Guidance literature:

In ethanol; for 2.5h; Heating;

DOI:10.1211/0022357021778871

Reference yield: 90.0%

methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate (468096-16-4) → 3-(4-chlorophenyl)-2-mercaptothieno[2,3-d]pyrimidin-4(3H)-one (468096-21-1)

Guidance literature:

With potassium hydroxide; In water; for 1h; Heating;

DOI:10.1211/0022357021778871

Reference yield: 79.0%

methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate (468096-16-4) → 3-(4-chlorophenyl)-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one

Guidance literature:

methyl 2-({[(4-chlorophenyl)amino]carbonothioyl}amino)thiophene-3-carboxylate; With potassium hydroxide; In methanol; at 20 ℃; for 0.666667h;

With hydrogenchloride; In methanol; water;

upstream raw materials:

Methyl 2-aminothiophene-3-carboxylate

4-Chlorophenyl isothiocyanate

Downstream raw materials:

3-(4-chlorophenyl)-2-mercaptothieno[2,3-d]pyrimidin-4(3H)-one

3-(4-chlorophenyl)-2-{[2-(diethylamino)ethyl]thio}thieno[2,3-d]pyrimidin-4(3H)-one

3-(4-chlorophenyl)-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one