(2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Base Information

Chemical Name:(2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester
CAS No.:1403898-70-3
Molecular Formula:C₁₉H₂₈N₂O₅
Molecular Weight:364.442
Hs Code.:

Synonyms:(2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Suppliers and Price of (2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

There total 5 articles about (2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1403898-64-5
(2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylic acid tert-butyl ester

: 501-53-1,94274-21-2
benzyl chloroformate

: 1403898-70-3
(2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 - 10 ℃; for 1h; Inert atmosphere;

Reference yield:

: [(2R,5R)-5-methylpiperazin-2-yl]methanol dihydrochloride

: 1403898-70-3
(2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / methanol / 0.5 h / 0 - 10 °C / Inert atmosphere

1.2: 1 h / 20 - 100 °C / pH 9 / Cooling with ice

2.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

: 1403898-62-3,13174-73-7,342416-68-6
(3S,6R)-3-(hydroxymethyl)-6-methylpiperazine-2,5-dione

: 1403898-70-3
(2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; borane / tetrahydrofuran / 2 h / 20 - 70 °C / Cooling with ice; Inert atmosphere

2.1: triethylamine / methanol / 0.5 h / 0 - 10 °C / Inert atmosphere

2.2: 1 h / 20 - 100 °C / pH 9 / Cooling with ice

3.1: sodium hydroxide / water; tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere

With hydrogenchloride; borane; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water;