(2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester

Base Information

Chemical Name:(2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester
CAS No.:1403898-73-6
Molecular Formula:C₂₁H₃₂N₂O₅
Molecular Weight:392.495
Hs Code.:

Synonyms:(2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester

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Chemical Property of (2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester

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Technology Process of (2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester

There total 5 articles about (2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1403898-72-5
(2R,5R)-5-methoxymethyl-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 5437-45-6
Benzyl bromoacetate

: 1403898-73-6
(2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 1403898-71-4
(2R,5R)-2-methoxymethyl-5-methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tertbutylester

: 1403898-73-6
(2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C / 750.08 Torr

2: potassium carbonate / acetonitrile / 18 h / 20 °C

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; acetonitrile;

Reference yield:

: 1403898-70-3
(2R,5R)-2-hydroxymethyl-5-methylpiperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 1403898-73-6
(2R,5R)-4-benzyloxycarbonylmethyl-5-methoxymethyl-2-methyl-piperazine-1-carboxylicacid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trimethoxonium tetrafluoroborate / 0.58 h / 4 - 5 °C

1.2: 1 h / 5 - 17 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C / 750.08 Torr

3.1: potassium carbonate / acetonitrile / 18 h / 20 °C

With palladium 10% on activated carbon; hydrogen; trimethoxonium tetrafluoroborate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; In methanol; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00706