((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol

Base Information

Chemical Name:((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol
CAS No.:949148-91-8
Molecular Formula:C₁₉H₃₀O₂Si
Molecular Weight:318.531
Hs Code.:

Synonyms:((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol

Suppliers and Price of ((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol

There total 4 articles about ((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₈O₂Si

: 949148-91-8
((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol

Guidance literature:: With hydrogen; Wilkinson's catalyst; at 20 ℃; for 16h; under 3878.71 Torr;
DOI:10.1021/ol701427k

Reference yield:

: 949148-90-7
methyl (2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyl-5,6-dihydro-2H-pyran-2-carboxylate

: 949148-91-8
((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium hydride / diethyl ether / 0.67 h / 0 °C

2: 350 mg / H₂ / chlorotris(triphenylphosphine)rhodium / 16 h / 20 °C / 3878.71 Torr

With lithium aluminium tetrahydride; hydrogen; Wilkinson's catalyst; In diethyl ether;
DOI:10.1021/ol701427k

Reference yield:

: (E)-3-(benzyldimethylsilyl)-2-methylprop-2-en-1-ol

: 949148-91-8
((2R,5S,6S)-6-((E)-1-(benzyldimethylsilyl)prop-1-en-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / MnO₂ / CH₂Cl₂ / 0.17 h / 20 °C

2: 65 percent / 2,6-di-tert-butylpyridine; trimethylsilyl trifluoromethanesulfonate / acetonitrile; CH₂Cl₂ / -78 - -20 °C

3: lithium aluminium hydride / diethyl ether / 0.67 h / 0 °C

4: 350 mg / H₂ / chlorotris(triphenylphosphine)rhodium / 16 h / 20 °C / 3878.71 Torr

With manganese(IV) oxide; lithium aluminium tetrahydride; 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate; hydrogen; Wilkinson's catalyst; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/ol701427k