methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Base Information

Chemical Name:methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate
CAS No.:1428796-48-8
Molecular Formula:C₂₄H₂₅NO₄
Molecular Weight:391.467
Hs Code.:

Synonyms:methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

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Chemical Property of methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Chemical Property:

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Technology Process of methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

There total 1 articles about methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41143-95-7
6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid

: 922-67-8
propynoic acid methyl ester

: 6613-44-1
3,5-dimethylbenzoyl chloride

: 1428796-48-8
methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Guidance literature:: 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid; 3,5-dimethylbenzoyl chloride; In tetrahydrofuran; at 150 ℃; for 0.0833333h; Molecular sieve; Microwave irradiation;

propynoic acid methyl ester; With acetic anhydride; In tetrahydrofuran; at 150 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 1428796-48-8
methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

: 1428796-49-9
3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylic acid

Guidance literature:: methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate; With water; lithium hydroxide; In 1,4-dioxane; at 180 ℃; for 0.0833333h; Microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; water; pH=2;

Reference yield:

: 1428796-48-8
methyl 3-(3,5-dimethylphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

: 1428795-70-3
(R)-3-(3,5-dimethylphenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / 1,4-dioxane / 0.08 h / 180 °C / Microwave irradiation

1.2: pH 2

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;