trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

Base Information

Chemical Name:trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
CAS No.:1319742-68-1
Molecular Formula:C₂₃H₁₉Cl₂F₅N₂O₂
Molecular Weight:521.314
Hs Code.:

Synonyms:trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

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Chemical Property of trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

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Technology Process of trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

There total 6 articles about trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6341-92-0
6-chloroisatin

: 1319742-68-1
trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; toluene / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 48 h / 50 °C / Inert atmosphere

With sodium hydride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1319743-47-9
6-chloro-3,3-difluoro-1,3-dihydro-indol-2-one

: 1319743-48-0
trans-methanesulfonic acid 4-(2-chloro-5-trifluoromethyl-benzoylamino)-cyclohexyl methyl ester

: 1319742-68-1
trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 48h; Inert atmosphere;

Reference yield:

: 657-05-6
2-chloro-5-trifluoromethylbenzoyl chloride

: 1319742-68-1
trans-2-chloro-N-[4-(6-chloro-3,3-difluoro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1.83 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

2.2: 0 °C

3.1: triethylamine / tetrahydrofuran; dichloromethane / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 48 h / 50 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;