methyl 4-aminocyclohexane-1-carboxylate

Base Information

• Chemical Name: methyl 4-aminocyclohexane-1-carboxylate
• CAS No.: 61367-07-5
• Molecular Formula: C₈H₁₅NO₂*ClH
• Molecular Weight: 193.674
• Hs Code.: 2922499990
• Mol file: 61367-07-5.mol

Synonyms:Cyclohexanecarboxylicacid, 4-amino-, methyl ester, hydrochloride, trans- (9CI); Methyltrans-4-aminocyclohexanecarboxylate hydrochloride;trans-4-Aminocyclohexanecarboxylic acid methyl ester hydrochloride

Chemical Property of methyl 4-aminocyclohexane-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.0129mmHg at 25°C
• Boiling Point: 255.4°C at 760 mmHg
• Flash Point: 108.3°C
• PSA: 52.32000
• LogP: 2.17920
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride >98.0%(N)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl trans-4-aminocyclohexanecarboxylate hydrochloride is generally used as a intermediate in pharmaceutical and chemical research.

Technology Process of methyl 4-aminocyclohexane-1-carboxylate

There total 2 articles about methyl 4-aminocyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

methanol (67-56-1) + trans-4-aminocyclohexanecarboxylic acid (1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7) → trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride (61367-07-5,61367-16-6,100707-54-8)

Guidance literature:

With thionyl chloride; at -10 ℃; for 1.5h; Reflux;

Reference yield:

methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate (146307-51-9) → trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride (61367-07-5,61367-16-6,100707-54-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 19h;

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride (61367-07-5,61367-16-6,100707-54-8) → methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate (146307-51-9)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at 0 - 23 ℃; for 1.16667h;

DOI:10.1016/j.bmc.2019.115193

upstream raw materials:

methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate

methanol

trans-4-aminocyclohexanecarboxylic acid

Downstream raw materials:

methyl trans-4-[(3-hydroxypropanoyl)amino]cyclohexanecarboxylate

methyl trans-4-(morpholin-4-ylcarbonyl)cyclohexane carboxylate

methyl trans-4-(pyrrolidin-1-ylcarbonyl)cyclohexane carboxylate

methyl trans-4-({2-[(t-butoxycarbonyl)amino]ethyl}amino)-cyclohexanecarboxylate

Refernces

• 1、 -. "NITROGENOUS FUSED BICYCLIC COMPOUND". Page/Page column 56. . Retrieved 2010/11/26.