tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate

Base Information

• Chemical Name: tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate
• CAS No.: 1198757-20-8
• Molecular Formula: C₃₇H₄₈N₂O₁₀P₂
• Molecular Weight: 742.743
• Mol file: 1198757-20-8.mol

Synonyms:tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate

Chemical Property of tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate

There total 2 articles about tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

vanillin (121-33-5,8014-42-4) + 4,4'-diamino diphenyl methane (101-77-9) + phosphonic acid diethyl ester (762-04-9) → tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate (1198757-20-8)

Guidance literature:

With iron(III) chloride; In tetrahydrofuran; at 60 ℃; for 1h;

DOI:10.1016/j.ejmech.2009.07.009

Reference yield: 93.3%

vanillin (121-33-5,8014-42-4) + 4,4'-diamino diphenyl methane (101-77-9) → tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate (1198757-20-8)

Guidance literature:

vanillin; 4,4'-diamino diphenyl methane; In ethanol; at 25 - 40 ℃; for 1.5h; Reflux;

With phosphonic acid diethyl ester; zinc(II) chloride; In ethanol; at 40 - 80 ℃; Inert atmosphere;

DOI:10.1021/acs.macromol.7b00097

Reference yield: 93.5%

tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate (1198757-20-8) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((3-methoxy-4-(oxiran-2-ylmethoxy)phenyl)methylene)diphosphonate

Guidance literature:

tetraethyl(4,4′-methylenebis(4,1-phenylene)-bis(azanediyl))bis((4-hydroxy-3-methoxyphenyl)methylene)diphosphonate; epichlorohydrin; With tetrabutylammomium bromide; at 80 ℃; for 3h;

With sodium hydroxide; at 5 ℃; for 5h;

DOI:10.1021/acs.macromol.7b00097

upstream raw materials:

vanillin

4,4'-diamino diphenyl methane

phosphonic acid diethyl ester