(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol

Base Information

Chemical Name:(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol
CAS No.:143347-75-5
Molecular Formula:C₂₇H₄₀O₆S
Molecular Weight:492.677
Hs Code.:

Synonyms:(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol

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Chemical Property of (6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol

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Technology Process of (6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol

There total 5 articles about (6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143347-74-4
(6R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-one

: 143347-75-5
(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; L-Selectride; Yield given. Multistep reaction; 1) THF, -78 deg C;
DOI:10.1021/jo00045a013

Reference yield:

: 143347-66-4
(S)-1-iodo-2-methyl-5-(trimethyl)silyl-4-pentyne

: 143347-75-5
(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 2) TBAF / 1) DMF, 65 deg C, 2) THF, r.t.

3: 1) Li(s-Bu)3BH, 2) H₂O₂, NaOH / 1) THF, -78 deg C

With sodium hydroxide; tetrabutyl ammonium fluoride; dihydrogen peroxide; L-Selectride;
DOI:10.1021/jo00045a013

Reference yield:

: ((S)-5-Benzyloxy-4-methyl-pent-1-ynyl)-trimethyl-silane

: 143347-75-5
(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) LiDBB, 2) Ph₃P, imidazole, I₂ / 1) THF, -78 deg C, 2) CH₂Cl₂, r.t.

2: 2) TBAF / 1) DMF, 65 deg C, 2) THF, r.t.

4: 1) Li(s-Bu)3BH, 2) H₂O₂, NaOH / 1) THF, -78 deg C

With 1H-imidazole; sodium hydroxide; lithium 4,4′-di(tert-butyl)biphenyl; tetrabutyl ammonium fluoride; dihydrogen peroxide; iodine; L-Selectride; triphenylphosphine;
DOI:10.1021/jo00045a013