[(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane
CAS No.:143347-76-6
Molecular Formula:C₃₃H₅₄O₆SSi
Molecular Weight:606.94
Hs Code.:

[(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane

Synonyms:[(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane

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Chemical Property of [(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane

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Technology Process of [(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane

There total 8 articles about [(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 143347-75-5
(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undecan-9-ol

: 143347-76-6
[(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo00045a013

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 143347-76-6
[(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 2) TBAF / 1) DMF, 65 deg C, 2) THF, r.t.

3: 1) Li(s-Bu)3BH, 2) H₂O₂, NaOH / 1) THF, -78 deg C

4: 93 percent / imidazole, DMAP / dimethylformamide / Ambient temperature

With 1H-imidazole; dmap; sodium hydroxide; tetrabutyl ammonium fluoride; dihydrogen peroxide; L-Selectride; In N,N-dimethyl-formamide;
DOI:10.1021/jo00045a013

Reference yield:

: 143347-66-4
(S)-1-iodo-2-methyl-5-(trimethyl)silyl-4-pentyne

: 143347-76-6
[(6R,9R,11R)-11-((E)-(S)-5-Benzenesulfonyl-2,4-dimethyl-pent-1-enyl)-2,2-dimethyl-4-((S)-1-methyl-allyl)-1,3,7-trioxa-spiro[5.5]undec-9-yloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 2) TBAF / 1) DMF, 65 deg C, 2) THF, r.t.

3: 1) Li(s-Bu)3BH, 2) H₂O₂, NaOH / 1) THF, -78 deg C

4: 93 percent / imidazole, DMAP / dimethylformamide / Ambient temperature

With 1H-imidazole; dmap; sodium hydroxide; tetrabutyl ammonium fluoride; dihydrogen peroxide; L-Selectride; In N,N-dimethyl-formamide;
DOI:10.1021/jo00045a013