propofol chloroacetate

Base Information

Chemical Name:propofol chloroacetate
CAS No.:1440-78-4
Molecular Formula:C₁₄H₁₉ClO₂
Molecular Weight:254.757
Hs Code.:

Synonyms:propofol chloroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of propofol chloroacetate

Chemical Property:

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Technology Process of propofol chloroacetate

There total 1 articles about propofol chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.6%

: 2078-54-8
2,6-diisopropylphenol

: 79-04-9
chloroacetyl chloride

: 1440-78-4
propofol chloroacetate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

Reference yield: 84.0%

: 1440-78-4
propofol chloroacetate

: 54699-92-2
(4-Methyl-piperazin-1-yl)-acetic acid

: 2-(2,6-diisopropylphenoxy)-2-oxoethyl 2-(4-methylpiperazin-1-yl)acetate hydrochloride

Guidance literature:: propofol chloroacetate; (4-Methyl-piperazin-1-yl)-acetic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 6h;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.5h;

Reference yield: 76.29%

: 1440-78-4
propofol chloroacetate

: 98303-20-9
1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid

: C₂₅H₃₇NO₆

Guidance literature:: propofol chloroacetate; 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid; With sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 4h;
DOI:10.1021/acs.jmedchem.0c00698