(S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide

Base Information

Chemical Name:(S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide
CAS No.:1323433-88-0
Molecular Formula:C₂₆H₂₇N₃O₅
Molecular Weight:461.517
Hs Code.:

Synonyms:(S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide

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Chemical Property of (S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide

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Technology Process of (S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide

There total 6 articles about (S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1323434-07-6
(S)-methyl 2-(4-(3-oxo-3-(phenylamino)-2-(3-phenylpropanamido)propyl)phenoxy)acetate

: 1323433-88-0
(S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide

Guidance literature:: (S)-methyl 2-(4-(3-oxo-3-(phenylamino)-2-(3-phenylpropanamido)propyl)phenoxy)acetate; With hydroxylamine potassium salt; In methanol; for 0.5h;

With hydrogenchloride; water; pH=3 - 4;
DOI:10.1016/j.bmc.2011.06.046

Reference yield:

: 179631-88-0
(S)-tert-butyl (3-(4-hydroxyphenyl)-1-oxo-1-(phenylamino)propan-2-yl)carbamate

: 1323433-88-0
(S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 8 h / 20 °C

4.1: hydroxylamine potassium salt / methanol / 0.5 h

4.2: pH 3 - 4

With hydroxylamine potassium salt; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.06.046

Reference yield:

: 1323434-06-5
(S)-methyl 2-(4-(2-((tert-butoxycarbonyl)amino)-3-oxo-3-(phenylamino)propyl)phenoxy)acetate

: 1323433-88-0
(S)-3-(4-(2-(hydroxyamino)-2-oxoethoxy)phenyl)-N-phenyl-2-(3-phenylpropanamido)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 8 h / 20 °C

3.1: hydroxylamine potassium salt / methanol / 0.5 h

3.2: pH 3 - 4

With hydroxylamine potassium salt; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.06.046