(2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester

Base Information

Chemical Name:(2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester
CAS No.:161313-44-6
Molecular Formula:C₂₂H₂₅NO₇S
Molecular Weight:447.509
Hs Code.:

Synonyms:(2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester

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Chemical Property of (2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester

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Technology Process of (2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester

There total 15 articles about (2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50353-47-4
phenyl acetaldehyde cyanohydrin

: 161313-44-6
(2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; hydrogenchloride / 1 h / 95 °C

2.1: (2S)-2-phenylglycinol / iso-butanol / 80 - 115 °C / Resolution of racemate

2.2: Resolution of racemate

3.1: 5% rhodium-on-charcoal; hydrogen / ethanol / 3 h / 50 °C / 11251.1 Torr

4.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 40 °C

5.1: 4-methyl-morpholine; dmap / toluene / 20 - 50 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; 5% rhodium-on-charcoal; (2S)-2-phenylglycinol; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; In ethanol; acetone; toluene; iso-butanol;
DOI:10.1021/op030202q

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 161313-45-7
(2R)-2-hydroxy-3-cyclohexyl-propionic acid benzyl ester

: 161313-44-6
(2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; dmap; In toluene; at 20 - 50 ℃;
DOI:10.1021/op030202q

Reference yield:

: 128659-92-7
(R)-methyl 2-hydroxy-3-cyclohexylpropanoate

: 161313-44-6
(2R)-2-(4-nitrophenyl)sulfonyloxy-3-cyclohexyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / water; methanol / 25 °C

1.2: Amberlyst IR-120 H⁺-form

2.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 40 °C

3.1: 4-methyl-morpholine; dmap / toluene / 20 - 50 °C

With 4-methyl-morpholine; dmap; lithium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; In methanol; water; acetone; toluene;
DOI:10.1021/op030202q