(S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride

Base Information

Chemical Name:(S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride
CAS No.:1448459-92-4
Molecular Formula:C₂₁H₂₂N₄O₂*ClH
Molecular Weight:398.892
Hs Code.:

Synonyms:(S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride

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Chemical Property of (S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride

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Technology Process of (S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride

There total 3 articles about (S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1448459-88-8
(S)-methyl 2-acetamido-3-(2-(dibenzylamino)pyrimidin-5-yl)propanoate

: 1448459-92-4
(S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride

Guidance literature:: With hydrogenchloride; In water; acetone; at 110 ℃; for 6h;
DOI:10.1016/j.tetlet.2013.06.066

Reference yield:

: 1448459-81-1
N,N-dibenzyl-5-iodopyrimidin-2-amine

: 1448459-92-4
(S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(o-tolyl)phosphine; sodium hydrogencarbonate; tetrabutyl-ammonium chloride; palladium dichloride / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 1,2-bis((2S,5S)-2,5-dimethylphospholano)benzene; hydrogen / methanol / 24 h / 20 °C / 26252.6 Torr / Autoclave

3: hydrogenchloride / water; acetone / 6 h / 110 °C

With hydrogenchloride; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; 1,2-bis((2S,5S)-2,5-dimethylphospholano)benzene; tris-(o-tolyl)phosphine; palladium dichloride; In methanol; water; N,N-dimethyl-formamide; acetone; 1: |Heck Reaction;
DOI:10.1016/j.tetlet.2013.06.066

Reference yield:

: 100-39-0
benzyl bromide

: 1448459-92-4
(S)-1-carboxy-2-(2-(dibenzylamino)pyrimidin-5-yl)ethanaminium chloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 19.5 h / 0 - 20 °C / Inert atmosphere

2: tris-(o-tolyl)phosphine; sodium hydrogencarbonate; tetrabutyl-ammonium chloride; palladium dichloride / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

3: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 1,2-bis((2S,5S)-2,5-dimethylphospholano)benzene; hydrogen / methanol / 24 h / 20 °C / 26252.6 Torr / Autoclave

4: hydrogenchloride / water; acetone / 6 h / 110 °C

With hydrogenchloride; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; tetrabutyl-ammonium chloride; hydrogen; sodium hydride; sodium hydrogencarbonate; 1,2-bis((2S,5S)-2,5-dimethylphospholano)benzene; tris-(o-tolyl)phosphine; palladium dichloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; mineral oil; 2: |Heck Reaction;
DOI:10.1016/j.tetlet.2013.06.066