1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

Base Information

Chemical Name:1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one
CAS No.:1588423-11-3
Molecular Formula:C₂₁H₁₆F₃N₅O
Molecular Weight:411.386
Hs Code.:

Synonyms:1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

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Chemical Property of 1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

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Technology Process of 1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

There total 9 articles about 1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1588424-37-6
C₂₁H₁₄F₃N₇O

: 1588423-11-3
1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

Guidance literature:: C₂₁H₁₄F₃N₇O; With trimethylphosphane; In tetrahydrofuran; at 20 ℃; for 1h;

With water; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1588423-09-9
3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

: 1588423-11-3
1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 2 h / 120 °C

3.1: trimethylphosphane / tetrahydrofuran / 1 h / 20 °C

3.2: 2 h / 20 °C

With sodium azide; triethylamine; trimethylphosphane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1060811-62-2
2,4-dichloro-5-pyridinecarboxaldehyde

: 1588423-11-3
1-(2-aminoethyl)-3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetonitrile / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C / Inert atmosphere

3.1: silver(I) nitrite; pyridine / tetrahydrofuran / 0 - 20 °C

4.1: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / -40 °C

6.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

7.1: sodium azide / N,N-dimethyl-formamide / 2 h / 120 °C

8.1: trimethylphosphane / tetrahydrofuran / 1 h / 20 °C

8.2: 2 h / 20 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; silver(I) nitrite; sodium azide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; sodium t-butanolate; XPhos; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;