3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

Base Information

Chemical Name:3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one
CAS No.:1588423-09-9
Molecular Formula:C₂₁H₁₅F₃N₄O₂
Molecular Weight:412.371
Hs Code.:

Synonyms:3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

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Chemical Property of 3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

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Technology Process of 3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

There total 6 articles about 3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1588424-34-3
C₂₇H₂₉F₃N₄O₂Si

: 1588423-09-9
3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -40 ℃; for 1h;

Reference yield:

: 1060811-62-2
2,4-dichloro-5-pyridinecarboxaldehyde

: 1588423-09-9
3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C / Inert atmosphere

3: silver(I) nitrite; pyridine / tetrahydrofuran / 0 - 20 °C

4: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / -40 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; silver(I) nitrite; tetrabutyl ammonium fluoride; potassium carbonate; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1588424-33-2
C₂₂H₂₅ClF₂N₂O₂Si

: 1588423-09-9
3-(2,6-difluorophenyl)-7-((5-fluoropyridin-2-yl)amino)-1-(2-hydroxyethyl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / -40 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane;