(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

Base Information

Chemical Name:(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide
CAS No.:1263387-04-7
Molecular Formula:C₂₅H₂₁ClFN₅O₂
Molecular Weight:477.925
Hs Code.:

Synonyms:(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

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Chemical Property of (E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

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Technology Process of (E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

There total 1 articles about (E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1245710-86-4
{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester

: 1263387-04-7
(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water;
DOI:10.1002/jlcr.3170

Reference yield:

: 1159266-05-3
2-[¹⁸F]fluoro-2-deoxy-β-D-glucopyranosyl azide

: 1263387-04-7
(E)-4-prop-2-ynylaminobut-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-amide

: 1563242-24-9
C₃₁H₃₁ClF⁽¹⁸⁾FN₈O₆

Guidance literature:: With copper(ll) sulfate pentahydrate; bathophenanthroline disulfonic acid disodium salt; sodium L-ascorbate; In aq. phosphate buffer; water; acetonitrile; at 20 ℃; for 0.0833333h;
DOI:10.1002/jlcr.3170