5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride

Base Information

Chemical Name:5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride
CAS No.:915233-34-0
Molecular Formula:C₁₃H₁₂FN₃O*ClH
Molecular Weight:281.717
Hs Code.:

Synonyms:5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride

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Chemical Property of 5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride

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Technology Process of 5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride

There total 3 articles about 5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 915233-33-9
5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 915233-34-0
5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 86447-11-2
1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid

: 915233-34-0
5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / 1,4-dioxane / 20 °C / Heating / reflux

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 6027-91-4
1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride

: 915233-34-0
5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-1,2,3,6-tetrahydro-pyridine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 1,4-dioxane; water / pH 11

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / 1,4-dioxane / 20 °C / Heating / reflux

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;