1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

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Chemical Name:1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
CAS No.:1279116-37-8
Molecular Formula:C₂₂H₁₉ClN₂O₅
Molecular Weight:426.856
Hs Code.:

Synonyms:1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

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Chemical Property of 1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

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Technology Process of 1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

There total 3 articles about 1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1279116-36-7
4-bromo-7-chloro-3,4-dihydrobenzo[b]oxepin-5(2H)-one

: 57-30-7
phenobartital sodium

: 1279116-37-8
1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 8h;
DOI:10.1007/s00044-011-9579-3

Reference yield:

: 3547-07-7
γ-(4-chlorophenoxy)-butyric acid

: 1279116-37-8
1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus pentoxide / toluene / 4 h / Reflux

2: copper(ll) bromide / chloroform; ethyl acetate / 0.5 - 1 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C

With phosphorus pentoxide; potassium carbonate; copper(ll) bromide; In chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1007/s00044-011-9579-3

Reference yield:

: 55579-90-3
7-chloro-3,4-dihydrobenzo[b]oxepin-5(2H)-one

: 1279116-37-8
1-(7-chloro-2,3,4,5-tetrahydro-5-oxobenzo[b]oxepin-4-yl)-5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide / chloroform; ethyl acetate / 0.5 - 1 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C

With potassium carbonate; copper(ll) bromide; In chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1007/s00044-011-9579-3