1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Name:1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:1417565-47-9
Molecular Formula:C₁₈H₁₂ClF₃N₄O₂
Molecular Weight:408.767
Hs Code.:

Synonyms:1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of 1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of 1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 3 articles about 1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.2%

: 438450-39-6
1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 84902-24-9
2-amino-3-methylbenzaldehyde

: 1417565-47-9
1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: 1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

2-amino-3-methylbenzaldehyde; With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2012.11.045

Reference yield:

: 57772-50-6
2-amino-3-methylbenzyl alcohol

: 1417565-47-9
1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 2 h / 0 - 20 °C

With manganese(IV) oxide; oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.045

Reference yield:

: 4389-45-1
3-methylantranilic acid

: 1417565-47-9
1-(3-chloropyridin-2-yl)-N-(2-formyl-6-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 2 h / 0 - 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.045