2-AMINO-3-METHYLBENZYL ALCOHOL

Base Information

• Chemical Name: 2-AMINO-3-METHYLBENZYL ALCOHOL
• CAS No.: 57772-50-6
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2922199090
• Mol file: 57772-50-6.mol

Synonyms:(2-AMINO-3-METHYL-PHENYL)-METHANOL;2-AMINO-3-METHYLBENZYL ALCOHOL

Chemical Property of 2-AMINO-3-METHYLBENZYL ALCOHOL

Chemical Property:

• Vapor Pressure: 0.000874mmHg at 25°C
• Melting Point: 67-69 °C(lit.)
• Refractive Index: 1.601
• Boiling Point: 291.8oC at 760 mmHg
• PKA: 14.48±0.10(Predicted)
• Flash Point: 130.3oC
• PSA: 46.25000
• Density: 1.126g/cm3
• LogP: 1.65070
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

(2-Amino-3-methylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-3-methylbenzyl alcohol may be used in chemical synthesis.

Technology Process of 2-AMINO-3-METHYLBENZYL ALCOHOL

There total 9 articles about 2-AMINO-3-METHYLBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methylantranilic acid (4389-45-1) → 2-amino-3-methylbenzyl alcohol (57772-50-6)

Guidance literature:

3-methylantranilic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With water; sodium hydroxide; In tetrahydrofuran;

DOI:10.1039/c6cc08731k

Reference yield: 98.0%

methyl 2-amino-3-methylbenzoate (22223-49-0) → 2-amino-3-methylbenzyl alcohol (57772-50-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield: 98.0%

2-methyl-6-hydroxymethyl-1-nitrobenzene (80866-76-8) → 2-amino-3-methylbenzyl alcohol (57772-50-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 4h; under 3102.9 Torr;

DOI:10.1021/jm00108a003

upstream raw materials:

3-methylantranilic acid

2-methyl-6-hydroxymethyl-1-nitrobenzene

sulfuric acid

7-methyl-1H-indole-2,3-dione

Downstream raw materials:

ω-Chlor-2-hydroxymethyl-6-methylacetanilid

2-amino-3-methylbenzaldehyde

2-azido-3-methylbenzyl alcohol

(E)-3-(2-Hydroxymethyl-6-methyl-phenylcarbamoyl)-acrylic acid ethyl ester