[1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine

Base Information

Chemical Name:[1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine
CAS No.:335595-83-0
Molecular Formula:C₄₄H₄₉N₅O₇Si
Molecular Weight:788.977
Hs Code.:

[1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N<sup>6</sup>-benzoyladenosine

Synonyms:[1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine

Chemical Property:

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Technology Process of [1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine

There total 15 articles about [1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 335595-80-7
[1'-13C]-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine

: 335595-83-0
[1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine

Guidance literature:: With silver nitrate; In tetrahydrofuran; for 1h;
DOI:10.1016/S0008-6215(00)00327-X

Reference yield:

: 4005-49-6
N-benzoyladenine

: 335595-83-0
[1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine

Guidance literature:: Multi-step reaction with 7 steps

1: (NH₄)2SO₄ / 14 h / Heating

2: 86 percent / TMSOTf / 1,2-dichloro-ethane / 5.5 h / 20 - 45 °C

3: 99 percent / NaOH / pyridine; ethanol / 0.5 h / 0 °C

4: 72 percent / AgNO₃ / dimethylformamide / 0.25 h / 20 °C

5: 74 percent / DMAP / pyridine / Heating

6: 96 percent / HF*pyridine / tetrahydrofuran / 0.08 h / 20 °C

7: 72 percent / AgNO₃ / tetrahydrofuran / 1 h

With dmap; ammonium sulfate; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; pyridine hydrogenfluoride; silver nitrate; In tetrahydrofuran; pyridine; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)00327-X

Reference yield:

: 18055-47-5
N-Benzoyl-N,9-bis(trimethylsilyl)adenin

: 335595-83-0
[1'-13C]-5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N⁶-benzoyladenosine

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / TMSOTf / 1,2-dichloro-ethane / 5.5 h / 20 - 45 °C

2: 99 percent / NaOH / pyridine; ethanol / 0.5 h / 0 °C

3: 72 percent / AgNO₃ / dimethylformamide / 0.25 h / 20 °C

4: 74 percent / DMAP / pyridine / Heating

5: 96 percent / HF*pyridine / tetrahydrofuran / 0.08 h / 20 °C

6: 72 percent / AgNO₃ / tetrahydrofuran / 1 h

With dmap; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; pyridine hydrogenfluoride; silver nitrate; In tetrahydrofuran; pyridine; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)00327-X