Benzamide, N-(trimethylsilyl)-N-[9-(trimethylsilyl)-9H-purin-6-yl]-

Base Information

• Chemical Name: Benzamide, N-(trimethylsilyl)-N-[9-(trimethylsilyl)-9H-purin-6-yl]-
• CAS No.: 18055-47-5
• Molecular Formula: C18H25N5OSi2
• Molecular Weight: 383.6
• DSSTox Substance ID: DTXSID00452368
• Nikkaji Number: J701.942D
• Wikidata: Q82272956
• Mol file: 18055-47-5.mol

Synonyms:18055-47-5;N-(Trimethylsilyl)-N-(9-(trimethylsilyl)-9H-purin-6-yl)benzamide;Benzamide, N-(trimethylsilyl)-N-[9-(trimethylsilyl)-9H-purin-6-yl]-;SCHEMBL5982855;DTXSID00452368;9,N-Bis(trimethylsilyl)-N-benzoyl-9H-purine-6-amine

Chemical Property of Benzamide, N-(trimethylsilyl)-N-[9-(trimethylsilyl)-9H-purin-6-yl]-

Chemical Property:

• Boiling Point: 454.1±50.0 °C(Predicted)
• PSA: 63.91000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 3.99100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 383.15976351
• Heavy Atom Count: 26
• Complexity: 513

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)N1C=NC2=C1N=CN=C2N(C(=O)C3=CC=CC=C3)[Si](C)(C)C
• Uses: N-Benzoyl-N,9-bis(trimethylsilyl)adenine is an intermediate in the proposed R&D synthesis of 2,3,5-Tri-O-acetyl α-Adenosine (T733805), an Adenosine (A280400(P)) impurity.

Technology Process of Benzamide, N-(trimethylsilyl)-N-[9-(trimethylsilyl)-9H-purin-6-yl]-

There total 7 articles about Benzamide, N-(trimethylsilyl)-N-[9-(trimethylsilyl)-9H-purin-6-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + N-benzoyladenine (4005-49-6) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → N-Benzoyl-N,9-bis(trimethylsilyl)adenin (18055-47-5)

Guidance literature:

Multistep reaction; 1.) pyridine, 10 min, reflux, 2.) 4 h, reflux;

Reference yield:

N,O-bis-(trimethylsilyl)-acetamide (10416-59-8) + N-benzoyladenine (4005-49-6) → N-Benzoyl-N,9-bis(trimethylsilyl)adenin (18055-47-5)

Guidance literature:

In acetonitrile;

DOI:10.1039/c39940001009 DOI:10.1021/jo00095a060

Reference yield:

N-benzoyladenine (4005-49-6) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → N-Benzoyl-N,9-bis(trimethylsilyl)adenin (18055-47-5)

Guidance literature:

With chloro-trimethyl-silane; for 7h; Heating;

upstream raw materials:

chloro-trimethyl-silane

N-benzoyladenine

N,O-bis-(trimethylsilyl)-acetamide

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

6-N-benzoyl-2',3',5'-tri-O-benzoyl-β-L-adenosine

C₃₇H₂₇N₅O₇

C₃₇H₂₇N₅O₇

(2S,5S)-5-Azido-6-[(2R,3R,4R,5R)-3,4-diacetoxy-5-(6-benzoylamino-purin-9-yl)-tetrahydro-furan-2-yl]-2-(toluene-4-sulfonylamino)-hexanoic acid tert-butyl ester