(3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol

Base Information

Chemical Name:(3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol
CAS No.:863554-29-4
Molecular Formula:C₁₈H₂₆O₇
Molecular Weight:354.4
Hs Code.:

Synonyms:(3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol

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Chemical Property of (3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol

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Technology Process of (3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol

There total 6 articles about (3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 863554-28-3
(3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran

: 863554-29-4
(3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol

Guidance literature:: With hydrogen; W-2 Raney Ni; In ethanol; at 0 ℃; for 48h; under 760 Torr;
DOI:10.1002/hlca.200590099

Reference yield:

: 863554-22-7
methyl 6-O-benzyl-3,4-O-isopropylidene-α-D-altropyranoside

: 863554-29-4
(3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.25 h / 0 °C

1.2: 95 percent / dimethylformamide / 0 - 20 °C

2.1: 100 percent / hydrogen / W-2 Raney Ni / ethanol / 48 h / 0 °C / 760 Torr

With hydrogen; sodium hydride; W-2 Raney Ni; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590099

Reference yield:

: 863554-21-6
methyl 2-O-allyl 6-O-benzyl-α-D-altropyranoside

: 863554-29-4
(3aR,4R,6S,7S,7aR)-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran-4-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 81 percent / TsOH / acetone / 1 h

2.1: 1,4-diazabicyclo[2.2.2]octane; [RhCl(Ph₃P)3] / ethanol; benzene; H₂O / 18 h / Heating

2.2: 85 percent / mercury(II) oxide; mercury(II) chloride / acetone; H₂O / 0.5 h

3.1: NaH / dimethylformamide / 0.25 h / 0 °C

3.2: 95 percent / dimethylformamide / 0 - 20 °C

4.1: 100 percent / hydrogen / W-2 Raney Ni / ethanol / 48 h / 0 °C / 760 Torr

With 1,4-diaza-bicyclo[2.2.2]octane; tris(triphenylphosphine)rhodium(I) chloride; hydrogen; sodium hydride; toluene-4-sulfonic acid; W-2 Raney Ni; In ethanol; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1002/hlca.200590099