benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

Base Information

• Chemical Name: benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester
• CAS No.: 639503-06-3
• Molecular Formula: C₂₇H₂₃NO₅
• Molecular Weight: 441.483
• Mol file: 639503-06-3.mol

Synonyms:benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

Chemical Property of benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

There total 4 articles about benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]-2,5-dihydropyrrolidin-1-yl]-(2R)-2-phenylethyl ester (639503-04-1) → benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester (639503-06-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0957-4166(03)00592-5

Reference yield:

methyl o-formylbenzoate (4122-56-9) → benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester (639503-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / -78 °C

2: 95 percent / SiO₂ / CH₂Cl₂; methanol / 2 h / 20 °C

3: 90 percent / H₂ / Pd/C / methanol

With boron trifluoride diethyl etherate; hydrogen; silica gel; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0957-4166(03)00592-5

Reference yield:

(2R)-2-<2-(tert-Butyldimethylsiloxy)pyrrol-1-yl>-2-phenylethylbenzoate (228098-63-3) → benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester (639503-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / -78 °C

2: 95 percent / SiO₂ / CH₂Cl₂; methanol / 2 h / 20 °C

3: 90 percent / H₂ / Pd/C / methanol

With boron trifluoride diethyl etherate; hydrogen; silica gel; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0957-4166(03)00592-5

upstream raw materials:

benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]-2,5-dihydropyrrolidin-1-yl]-(2R)-2-phenylethyl ester

methyl o-formylbenzoate

(2R)-2-<2-(tert-Butyldimethylsiloxy)pyrrol-1-yl>-2-phenylethylbenzoate

2-{(S)-[(R)-1-((R)-2-Benzoyloxy-1-phenyl-ethyl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl]-hydroxy-methyl}-benzoic acid methyl ester

Downstream raw materials:

benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester