benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

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Chemical Name:benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester
CAS No.:639503-08-5
Molecular Formula:C₂₇H₂₅NO₄
Molecular Weight:427.5
Hs Code.:

Synonyms:benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

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Chemical Property of benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

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Technology Process of benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

There total 5 articles about benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 639503-06-3
benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

: 639503-08-5
benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

Guidance literature:: benzoic acid 2-[2-oxo-(5R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester; With boron trifluoride-tetrahydrofuran complex; In tetrahydrofuran; at 20 ℃; for 4h;

With water; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0957-4166(03)00592-5

Reference yield:

: 4122-56-9
methyl o-formylbenzoate

: 639503-08-5
benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / -78 °C

2.1: 95 percent / SiO₂ / CH₂Cl₂; methanol / 2 h / 20 °C

3.1: 90 percent / H₂ / Pd/C / methanol

4.1: BF₃*THF / tetrahydrofuran / 4 h / 20 °C

4.2: 81 percent / water / CH₂Cl₂ / 2 h / 20 °C

With boron trifluoride-tetrahydrofuran complex; boron trifluoride diethyl etherate; hydrogen; silica gel; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(03)00592-5

Reference yield:

: 228098-63-3
(2R)-2-<2-(tert-Butyldimethylsiloxy)pyrrol-1-yl>-2-phenylethylbenzoate

: 639503-08-5
benzoic acid 2-[(2R)-[(1S)-3-oxo-1,3-dihydroisobenzofuran-1-yl]pyrrolidin-1-yl]-(2R)-2-phenylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / -78 °C

2.1: 95 percent / SiO₂ / CH₂Cl₂; methanol / 2 h / 20 °C

3.1: 90 percent / H₂ / Pd/C / methanol

4.1: BF₃*THF / tetrahydrofuran / 4 h / 20 °C

4.2: 81 percent / water / CH₂Cl₂ / 2 h / 20 °C

With boron trifluoride-tetrahydrofuran complex; boron trifluoride diethyl etherate; hydrogen; silica gel; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(03)00592-5