(S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid

Base Information

Chemical Name:(S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid
CAS No.:137795-63-2
Molecular Formula:C₂₄H₃₁ClN₂O₄
Molecular Weight:446.974
Hs Code.:

Synonyms:(S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid

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Chemical Property of (S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid

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Technology Process of (S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid

There total 4 articles about (S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5680-86-4
N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid

: 137795-63-2
(S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, ethyl chloroformate / 1.) THF, -10 deg C, 15 min, 2.)a) THF, -10 deg C, 1 h, b) RT, 3 h

2: H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

3: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00079a003

Reference yield:

: 26482-53-1
2-(1-adamantyl)ethanamine

: 137795-63-2
(S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, ethyl chloroformate / 1.) THF, -10 deg C, 15 min, 2.)a) THF, -10 deg C, 1 h, b) RT, 3 h

2: H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

3: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00079a003

Reference yield:

: 137795-78-9
(S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-benzyloxycarbonylamino-butyric acid benzyl ester

: 137795-63-2
(S)-4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, H₂O / 10percent Pd/activated charcoal / methanol / 2 h / 760 Torr / Ambient temperature

2: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; water; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00079a003