(2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide

Base Information

Chemical Name:(2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide
CAS No.:1357181-77-1
Molecular Formula:C₁₆H₁₉NO₆S
Molecular Weight:353.396
Hs Code.:

Synonyms:(2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide

Suppliers and Price of (2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide

There total 4 articles about (2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl (Z)-2-iodo-4-oxobutenoate

: 1357181-77-1
(2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 3 h / 0 - 20 °C

2.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0.25 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

3.2: 2 h / 0 - 20 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / 80 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; copper(l) iodide; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; sodium hydride; In tetrahydrofuran; 1,4-dioxane; water; mineral oil; tert-butyl alcohol; 4.1: Migita-Stille coupling;
DOI:10.1016/j.tetlet.2011.12.014

Reference yield:

: 1357181-62-4
(Z)-4-ethoxy-3-iodo-4-oxobut-2-enoic acid

: 1357181-77-1
(2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 0 °C

1.2: 0.25 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / 80 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; mineral oil; 3.1: Migita-Stille coupling;
DOI:10.1016/j.tetlet.2011.12.014

Reference yield:

: 1373869-69-2
C₁₁H₁₅IO₆

: 1357181-77-1
(2E,4E)-3-ethoxycarbonyl-6-hydroxy-N-(p-toluenesulfonyl)-2,4-hexadienamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; mineral oil; 2.1: Migita-Stille coupling;
DOI:10.1016/j.tetlet.2011.12.014